Pla2g7 - phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Gene

Also known as PAF-AH

About Pla2g7

Summary

Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent Phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in several processes, including glycerophospholipid catabolic process; plasma lipoprotein particle remodeling; and positive regulation of monocyte chemotaxis. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasm and extracellular space. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (Phospholipase A2 group VII). [provided by Alliance of Genome Resources, Apr 2022]