Pdk4 - pyruvate dehydrogenase kinase, isoenzyme 4 Gene

Mus musculus

Gene ID: 27273 | Gene type: protein coding

About Pdk4

Summary

Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including Insulin Receptor signaling pathway; regulation of bone resorption; and regulation of fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skin. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Pdk4 Products(1)

mRNA	Protein	Name
NM_013743.2	NP_038771.1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16606348	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19627255	MGI
involved in regulation of acetyl-CoA biosynthetic process from pyruvate	IMP IMP: Inferred from mutant phenotype	16606348	MGI
involved in regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	21803180	MGI
involved in regulation of cellular ketone metabolic process	IMP IMP: Inferred from mutant phenotype	16606348	MGI
involved in regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	19627255	MGI
involved in regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	16606348	MGI
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	16606348	MGI
involved in regulation of pH	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in response to starvation	IMP IMP: Inferred from mutant phenotype	16606348	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial

pyruvate dehydrogenase kinase 4

Recombinant Pdk4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74639	PDK4 Protein, Mouse (sf9, His-GST)	O70571 (M1-V412)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121744	PS10	Inhibitor	99.01%	Unkown
HY-135954A	PDK4-IN-1 hydrochloride		99.51%	Unkown
HY-12492	VER-246608	Inhibitor	98.92%	Unkown
HY-114702	M77976	Inhibitor	99.27%	Unkown
HY-135954	PDK4-IN-1		98.82%	Unkown
HY-139185	PROTAC ERRα Degrader-3	Inhibitor	98.82%	Unkown
HY-156109	PDK-IN-2		/	Unkown
HY-157538	PDK4-IN-2	Inhibitor	/	Unkown
HY-RS10278	PDK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116257	GSK-7227		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdk4	NCBI	NCBI:5166

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