TINAG - tubulointerstitial nephritis antigen Gene

Homo sapiens

Also known as TIN-AG

Gene ID: 27283 | Gene type: protein coding

About TINAG

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:54,307,862-54,390,142 (from NCBI)

This gene has 4 transcripts (splice variants), 285 orthologues and 12 paralogues. Biased expression in kidney (RPKM 36.8), colon (RPKM 4.4) and 2 other tissues.

Summary

This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

TINAG Products(1)

mRNA	Protein	Name
NM_014464.4	NP_055279.3	tubulointerstitial nephritis antigen

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	8770961	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	1762287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TINAG Protein Structure

Somatomedin_B

Peptidase_C1

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

tubulointerstitial nephritis antigen

Related Diseases

Diseases

Alias

Membranous Nephropathy

Membranous Glomerulonephritis	Glomerulonephritis, Membranous
Idiopathic Membranous Nephropathy	Idiopathic Membranous Glomerulonephritis
MBNP	Membranous Nephropathy, Susceptibility To
Extramembranous Glomerulonephritis	Mgn
Membranous Gn	Primary Membranous Glomerulonephritis
Primary Membranous Nephropathy	Nephropathy Membranous

Interstitial Nephritis

Nephritis, Interstitial	Renal Tubulo-Interstitial Disease
Nephritis Interstitial	Nephritis, Tubulointerstitial

Tinea Barbae

Dermatophytosis Of Beard

Tinea Imbricata

Kerion Celsi	Trichophyton Infection
Tinea Imbricata, Susceptibility To	Susceptibility To Tinea Imbricata
Tinea Capitis Profunda	Trichophytia Profunda Barbae
Trichophytia Profunda Capitis	Tinea Capitis

Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand

Tinea Cruris

Dermatophytosis Of Groin & Perianal Area	Dermatophytosis Of Groin And Perianal Area
Dhobie Itch	Tinea Of Perianal Region

Tinea Unguium

Dermatophytosis Of Nail	Onychomycosis Due To Dermatophyte
Cellulitis And Abscess	Cellulitis And Abscess Of Buttock
Cellulitis And Abscess Of Face	Cellulitis And Abscess Of Finger
Cellulitis And Abscess Of Finger And Toe	Cellulitis And Abscess Of Gluteal Region
Cellulitis And Abscess Of Trunk	Cellulitis And Abscess Of Upper Arm And Forearm
Dermatophytic Onychia	Dermatophytic Onychomycosis
Onychomycosis	Ringworm Of Nails
Tinea Of Nail

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Tinea Capitis

Dermatophytosis Of Scalp	Scalp Ringworm
Dermatophytosis Of Scalp Or Beard	Tinea Capitis Due To Trichophyton Rubrum
Trichophyton Rubrum Tinea Capitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14542	TINAG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TINAG	VGNC	VGNC:35874
Rattus norvegicus	TINAG	RGD	RGD:1359482
Canis familiaris	TINAG	VGNC	VGNC:47379
Mus musculus	TINAG	MGD	MGI:1349477
Felis catus	TINAG	VGNC	VGNC:66195
Macaca mulatta	TINAG	VGNC	VGNC:78382
Others	TINAG	NCBI

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