DIMT1 - DIM1 rRNA methyltransferase and ribosome maturation factor Gene

Homo sapiens

Also known as DIM1; DIMT1L; HUSSY5; HSA9761

Gene ID: 27292 | Gene type: protein coding

About DIMT1

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:62,387,254-62,403,905 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in urinary bladder (RPKM 12.5), lymph node (RPKM 11.7) and 25 other tissues.

Summary

The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]

DIMT1 Products(3)

mRNA	Protein	Name
NM_001348076.2	NP_001335005.1	probable dimethyladenosine transferase isoform 2
NM_001348077.2	NP_001335006.1	probable dimethyladenosine transferase isoform 3
NM_014473.4	NP_055288.1	probable dimethyladenosine transferase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity	IMP IMP: Inferred from mutant phenotype	25851604	GOA
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	EXP EXP: Inferred from Experiment	25851604	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	25851604	GOA
involved in rRNA methylation	IMP IMP: Inferred from mutant phenotype	25851604	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	25851604	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIMT1 Protein Structure

RrnaAD

0
100
200
313 a.a.

Protein Preferred Names

Protein Names

probable dimethyladenosine transferase

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase

Related Diseases

Diseases

Alias

Localized Osteosarcoma

Localised Osteogenic Sarcoma	Localised Osteosarcoma
Localized Osteogenic Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03768	DIMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DIMT1	VGNC	VGNC:28065
Macaca mulatta	DIMT1	VGNC	VGNC:71818
Felis catus	DIMT1	VGNC	VGNC:61491
Rattus norvegicus	DIMT1	RGD	RGD:1311752
Canis familiaris	DIMT1	VGNC	VGNC:52127
Mus musculus	DIMT1	MGD	MGI:1913504

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