RAB30 - RAB30, member RAS oncogene family Gene

Homo sapiens

Gene ID: 27314 | Gene type: protein coding

About RAB30

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:82,973,133-83,071,897 (from NCBI)

This gene has 16 transcripts (splice variants), 203 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 7.4), lymph node (RPKM 5.8) and 24 other tissues.

Summary

Predicted to enable GTP binding activity and GTPase activity. Involved in Golgi organization. Located in Golgi cisterna; cis-Golgi network; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

RAB30 Products(4)

mRNA	Protein	Name
NM_001286059.2	NP_001272988.1	ras-related protein Rab-30
NM_001286060.2	NP_001272989.1	ras-related protein Rab-30
NM_001286061.1	NP_001272990.1	ras-related protein Rab-30
NM_014488.5	NP_055303.2	ras-related protein Rab-30

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	22188167	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi cisterna	IDA IDA: Inferred from direct assay	22188167	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	22188167	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	22188167	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB30 Protein Structure

Ras

0
100
203 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-30

RAB30 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB30	Q15771	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	RAB30	Q15771	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	RAB30	Q15771	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Shashi Type

Mental Retardation, X-Linked, Syndromic 11, Shashi Type	Mrxs11
Shashi X-Linked Mental Retardation Syndrome	Smrxs
Syndromic X-Linked Intellectual Disability Type 11	X-Linked Mental Retardation Shashi Type
Mental Retardation, X-Linked, Syndromic 11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11543	RAB30 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB30	RGD	RGD:1309507
Mus musculus	RAB30	MGD	MGI:1923235
Canis familiaris	RAB30	VGNC	VGNC:45273
Felis catus	RAB30	VGNC	VGNC:81955
Bos taurus	RAB30	VGNC	VGNC:33639
Macaca mulatta	RAB30	VGNC	VGNC:81531

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