TOX3 - TOX high mobility group box family member 3 Gene

Homo sapiens

Also known as CAGF9; TNRC9

Gene ID: 27324 | Gene type: protein coding

About TOX3

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:52,436,416-52,547,802 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in stomach (RPKM 5.0), colon (RPKM 3.6) and 13 other tissues.

Summary

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast Cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

TOX3 Products(2)

mRNA	Protein	Name
NM_001080430.4	NP_001073899.2	TOX high mobility group box family member 3 isoform 1
NM_001146188.2	NP_001139660.1	TOX high mobility group box family member 3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	21172805	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	21172805	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21172805	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21172805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	21172805	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21172805	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21172805	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	21172805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX3 Protein Structure

HMG_box

0
100
200
300
400
500
576 a.a.

Protein Preferred Names

Protein Names

TOX high mobility group box family member 3

CAG trinucleotide repeat-containing gene F9 protein

Related Diseases

Diseases

Alias

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Sporadic Breast Cancer

Sporadic Breast Carcinoma

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14910	TOX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TOX3	VGNC	VGNC:55004
Mus musculus	TOX3	MGD	MGI:3039593
Macaca mulatta	TOX3	VGNC	VGNC:78612
Rattus norvegicus	TOX3	RGD	RGD:1311529
Bos taurus	TOX3	VGNC	VGNC:36229

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