GNGT2 - G protein subunit gamma transducin 2 Gene

Homo sapiens

Also known as GNG9; HG3I; GNGT8; G-GAMMA-8; G-GAMMA-C

Gene ID: 2793 | Gene type: protein coding

About GNGT2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:49,206,234-49,210,574 (from NCBI)

This gene has 6 transcripts (splice variants), 170 orthologues and 11 paralogues. Broad expression in spleen (RPKM 5.8), lymph node (RPKM 4.5) and 21 other tissues.

Summary

Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]

GNGT2 Products(4)

mRNA	Protein	Name
NM_001198754.2	NP_001185683.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198755.1	NP_001185684.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198756.1	NP_001185685.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_031498.2	NP_113686.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	10570481	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of heterotrimeric G-protein complex	IDA IDA: Inferred from direct assay	10570481	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNGT2 Protein Structure

G-gamma

0
69 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

G protein cone gamma 8 subunit

Related Diseases

Diseases

Alias

Adenosquamous Lung Carcinoma

Night Blindness, Congenital Stationary, Autosomal Dominant 2

Congenital Stationary Night Blindness Autosomal Dominant 2	CSNBAD2
Hemeralopia	Night Blindness, Congenital Stationary, Rambusch Type
Rambusch Type Congenital Stationary Night Blindness	Congenital Stationary Night Blindness Rambusch Type
Hemeralopia Congenital Essential	Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS05563	GNGT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GNGT2	VGNC	VGNC:29471
Rattus norvegicus	GNGT2	RGD	RGD:1591007
Mus musculus	GNGT2	MGD	MGI:893584
Felis catus	GNGT2	VGNC	VGNC:99069
Canis familiaris	GNGT2	VGNC	VGNC:41325

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