2. Gene
  3. Spg21 - SPG21, maspardin Gene

Spg21 - SPG21, maspardin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MAST; ACP33; GL010; BM-019; D9Wsu18e

Gene ID: 27965 | Gene type: protein coding

About Spg21

Summary

Predicted to enable CD4 receptor binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and trans-Golgi network transport vesicle. Is expressed in extraembryonic component; head mesenchyme; tongue; and vertebral axis musculature. Used to study Mast syndrome. Human ortholog(s) of this gene implicated in Mast syndrome and hereditary spastic paraplegia. Orthologous to human SPG21 (SPG21 abhydrolase domain containing, maspardin). [provided by Alliance of Genome Resources, Apr 2022]

Spg21 Products(9)

mRNA Protein Name
NM_001357813.2 NP_001344742.1 maspardin isoform 1
NM_001413545.1 NP_001400474.1 maspardin isoform 2
NM_001413546.1 NP_001400475.1 maspardin isoform 3
NM_001413547.1 NP_001400476.1 maspardin isoform 4
NM_001413548.1 NP_001400477.1 maspardin isoform 5
NM_001413549.1 NP_001400478.1 maspardin isoform 5
NM_001413550.1 NP_001400479.1 maspardin isoform 6
NM_001413551.1 NP_001400480.1 maspardin isoform 7
NM_138584.3 NP_613050.1 maspardin isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell growth IMP
IMP: Inferred from mutant phenotype
26978163 MGI
acts upstream of or within collateral sprouting IMP
IMP: Inferred from mutant phenotype
20661613 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26978163 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
26978163 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
20661613 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
26978163 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
26978163 MGI
acts upstream of or within neuron maturation IMP
IMP: Inferred from mutant phenotype
26978163 MGI
acts upstream of or within response to epidermal growth factor IMP
IMP: Inferred from mutant phenotype
26978163 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

maspardin

acid cluster protein 33

spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog

spastic paraplegia 21 homolog

Recombinant Spg21 Proteins

Cat. No. Product Name Accession Purity
HY-P77213 SPG21 Protein, Mouse (sf9, His) Q9CQC8-1 (M1-P308) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13662 SPG21 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spg21 NCBI NCBI:51324