GOLGA3 - golgin A3 Gene

Homo sapiens

Also known as MEA-2; GCP170

Gene ID: 2802 | Gene type: protein coding

About GOLGA3

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,768,914-132,829,081 (from NCBI)

This gene has 41 transcripts (splice variants), 199 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 8.3), brain (RPKM 6.7) and 25 other tissues.

Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]

GOLGA3 Products(9)

mRNA	Protein	Name
NM_001172557.2	NP_001166028.1	golgin subfamily A member 3 isoform 2
NM_001389683.1	NP_001376612.1	golgin subfamily A member 3 isoform 1
NM_001389684.1	NP_001376613.1	golgin subfamily A member 3 isoform 1
NM_001389685.1	NP_001376614.1	golgin subfamily A member 3 isoform 1
NM_001389686.1	NP_001376615.1	golgin subfamily A member 3 isoform 3
NM_001389687.1	NP_001376616.1	golgin subfamily A member 3 isoform 3
NM_001389688.1	NP_001376617.1	golgin subfamily A member 3 isoform 3
NM_001389689.1	NP_001376618.1	golgin subfamily A member 3 isoform 4
NM_005895.4	NP_005886.2	golgin subfamily A member 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14522980	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	14522980	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14522980	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

golgin subfamily A member 3

Golgi membrane associated protein

Related Diseases

Diseases

Alias

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05584	GOLGA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GOLGA3	VGNC	VGNC:29484
Canis familiaris	GOLGA3	VGNC	VGNC:41339
Felis catus	GOLGA3	VGNC	VGNC:62638
Mus musculus	GOLGA3	MGD	MGI:96958
Macaca mulatta	GOLGA3	VGNC	VGNC:73106
Rattus norvegicus	GOLGA3	RGD	RGD:1305262

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