GPLD1 - glycosylphosphatidylinositol specific phospholipase D1 Gene

Homo sapiens

Also known as PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1

Gene ID: 2822 | Gene type: protein coding

About GPLD1

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,423,969-24,495,287 (from NCBI)

This gene has 6 transcripts (splice variants) and 126 orthologues. Biased expression in liver (RPKM 12.6), skin (RPKM 4.0) and 8 other tissues.

Summary

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading Enzyme. Glycosylphosphatidylinositol specific Phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

GPLD1 Products(1)

mRNA	Protein	Name
NM_001503.4	NP_001494.2	phosphatidylinositol-glycan-specific phospholipase D precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycosylphosphatidylinositol phospholipase D activity	IDA IDA: Inferred from direct assay	1833386	GOA
enables phospholipase D activity	IDA IDA: Inferred from direct assay	2760042	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in GPI anchor release	IDA IDA: Inferred from direct assay	2760042	GOA
involved in GPI anchor release	IMP IMP: Inferred from mutant phenotype	17720976	GOA
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	17720976	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	2760042	GOA
involved in cellular response to cholesterol	IMP IMP: Inferred from mutant phenotype	17761367	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	15907827	GOA
involved in cellular response to pH	IDA IDA: Inferred from direct assay	17761367	GOA
involved in cellular response to triglyceride	IMP IMP: Inferred from mutant phenotype	17761367	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	17761367	GOA
involved in complement receptor mediated signaling pathway	IDA IDA: Inferred from direct assay	15907827	GOA
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	18328347	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19135435	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	19135435	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17720976	GOA
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	17720976	GOA
involved in regulation of cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	18328347	GOA
involved in response to glucose	IDA IDA: Inferred from direct assay	15907827	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19135435	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	1833386	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	1833386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPLD1 Protein Structure

Zn_dep_PLPC

FG-GAP

0
200
400
600
840 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol-glycan-specific phospholipase D

GPI-PLD

Related Diseases

Diseases

Alias

Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria	Ssadh Deficiency
Gamma-Hydroxybutyric Aciduria	Gaba Metabolic Defect
SSADHD	Ssadh
Succinate-Semialdehyde Dehydrogenase Deficiency	Gamma-Hydroxybutyricaciduria
4-Hydroxybutyricaciduria	Gamma-Hydroxybutyric Acidemia
Succinate Semialdehyde Dehydrogenase Deficiency

Glandular Tularemia

Typhoidal Tularemia

Brill-Zinsser Disease

Recrudescent Typhus	Brill Disease
Brill Zinsser Disease	Brill'S Disease
Latent Typhus	Sporadic Typhus
Typhus, Epidemic Louse-Borne	Recrudescent Typhus Due To Rickettsia Prowazekii
Recrudescent Typhus Fever	Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii
Recrudescent Brill Disease	Recrudescent Typhus Fever Due To Rickettsia Prowazekii

Oculoglandular Tularemia

Epidemic Typhus

Typhus	Typhus Fever
Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii	Murine Typhus
Classical Typhus	Endemic Flea-Borne Typhus
Endemic Typhus Fever	Epidemic Louse-Borne Typhus
Famine Fever	Flea-Borne Typhus
Jail Fever	Louse-Borne Typhus
Mexican Typhus	Shop Typhus
Urban Typhus	Brill-Zinsser Disease
Endemic Typhus	Sylvatic Typhus
Epidemic Typhus	European Typhus
Exanthematic Typhus Fever	Exanthematous Typhus
Flea Typhus	Flea-Borne Rickettsiosis
Hospital Fever	Louse-Borne [Epidemic] Typhus
Louse-Borne Rickettsiosis	Moscow Typhus
Murine [Endemic] Typhus	Petechial Fever
Prison Fever	Rat Flea Typhus
Ship Fever	Typhus Exanthematique
Typhus, Endemic Flea-Borne	Typhus, Epidemic Louse-Borne
Typhus Group Rickettsial Disease	Relapsing Fever
Typhus Fever Nos	Typhus Nos
Epidemic Typhus Fever	Louse-Borne Typhus Fever
Classical Typhus Fever	Louse-Borne Tabardillo
Epidemic Typhus Fever Due To Rickettsia Prowazekii	Endemic Murine Typhus
Flea-Borne Typhus Fever	Murine Endemic Flea Typhus
Rat Typhus	Typhus Due To Rickettsia Typhi
Flea-Borne Tabardillo	Rickettsia Typhi Rickettsiosis
Mexican Fever	Murine Flea-Borne Typhus
Mooser Bodies	Tsutsugamushi Fever
Kedani Fever	Mite-Borne Typhus
Mite-Borne Typhus Due To Rickettsia Tsutsugamushi	Scrub Typhus
Tsutsugamushi	Tsutsugamushi Disease
Scrub Mite-Borne Typhus	Sumatran Mite Fever
Japanese River Fever	Kedani Typhus
Rickettsia Tsutsugamushi Rickettsiosis	Sumatran Mite Typhus
Tropical Typhus	Japanese Typhus

African Tick-Bite Fever

Rickettsia Africae Spotted Fever	South African Tick-Bite Fever
African Tick Bite Fever

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05642	GPLD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPLD1	VGNC	VGNC:67410
Macaca mulatta	GPLD1	VGNC	VGNC:73120
Bos taurus	GPLD1	VGNC	VGNC:29536
Mus musculus	GPLD1	MGD	MGI:106604
Rattus norvegicus	GPLD1	RGD	RGD:631371
Canis familiaris	GPLD1	VGNC	VGNC:41384

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