IFNL2 - interferon lambda 2 Gene

Homo sapiens

Also known as IL28A; IFNL2a; IFNL3a; IL-28A

Gene ID: 282616 | Gene type: protein coding

About IFNL2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,268,396-39,270,188 (from NCBI)

This gene has 1 transcript (splice variant), 136 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL2 Products(1)

mRNA	Protein	Name
NM_172138.2	NP_742150.1	interferon lambda-2 precursor

IFNL2 Protein Structure

IL28A

0
100
200 a.a.

Protein Preferred Names

Protein Names

interferon lambda-2

IFN-lambda-2

Recombinant IFNL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72553	IFN-lambda 2/IL-28A Protein, Human (HEK293, His)	Q8IZJ0 (V26-V200)	≥95%
HY-P77005	IFN-lambda 2/IL-28A Protein, Human (P.pastoris, His)	Q8IZJ0 (V26-V200)	≥95%
HY-P700119AF	Animal-Free IFN-lambda 2/IL-28A Protein, Human (His)	Q8IZJ0 (P27-V200)	≥95%

Related Diseases

Diseases

Alias

Psoriasis 12

PSORS12	Psoriasis Susceptibility 12
Psoriasis 12, Susceptibility To

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06592	IFNL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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