PROX2 - prospero homeobox 2 Gene

Homo sapiens

Also known as PROX-2

Gene ID: 283571 | Gene type: protein coding

About PROX2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:74,853,033-74,876,145 (from NCBI)

This gene has 3 transcripts (splice variants), 263 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PROX2 Products(3)

mRNA	Protein	Name
NM_001080408.3	NP_001073877.2	prospero homeobox protein 2 isoform 2
NM_001243007.2	NP_001229936.1	prospero homeobox protein 2 isoform 1
NM_001384314.1	NP_001371243.1	prospero homeobox protein 2 isoform 1

PROX2 Protein Structure

HPD

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

prospero homeobox protein 2

homeobox prospero-like protein PROX2

Related Diseases

Diseases

Alias

Atrial Septal Defect 6

ASD6	Atrial Heart Septal Defect 6
Septal Defect, Atrial, Type 6

Atrial Septal Defect 5

ASD5	Atrial Heart Septal Defect 5
Septal Defect, Atrial, Type 5

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11204	PROX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PROX2	VGNC	VGNC:99228
Canis familiaris	PROX2	VGNC	VGNC:45018
Mus musculus	PROX2	MGD	MGI:1920672
Bos taurus	PROX2	VGNC	VGNC:33370
Felis catus	PROX2	VGNC	VGNC:64368
Rattus norvegicus	PROX2	RGD	RGD:1310315

Name
Email *

	Sorry, but the email address you supplied was invalid.