2. Gene
  3. GPR18 - G protein-coupled receptor 18 Gene

GPR18 - G protein-coupled receptor 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 2841 | Gene type: protein coding

About GPR18

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,254,739-99,258,379 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 16 paralogues. Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR18 Products(2)

mRNA Protein Name
NM_001098200.2 NP_001091670.1 N-arachidonyl glycine receptor
NM_005292.4 NP_005283.1 N-arachidonyl glycine receptor

GPR18 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (40 - 286)

  • 0
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  • 331 a.a.
Protein Preferred Names Protein Names

N-arachidonyl glycine receptor

NAGly receptor

Related Diseases

Diseases Alias
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy

Severe Myoclonic Epilepsy In Infancy

Smei

Epileptic Encephalopathy, Early Infantile, 6

DRVT

Developmental And Epileptic Encephalopathy 6a

Dee6a

Eiee6

Developmental And Epileptic Encephalopathy, 6

Dee6

Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy

Sme

Severe Myoclonus Epilepsy Of Infancy

Borderline Smei

Smeb

Smeb-M

Smeb-O

Smeb-Sw

Smei-Borderland

Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

ICEGTC

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10863 Anandamide ≥99.0% Unkown
HY-103332 N-Arachidonylglycine Inhibitor 98.90% Unkown
HY-103335 O1918 Antagonist 96.60% Unkown
HY-162617 PSB-KK1415 Agonist 99.92% Unkown
HY-103332S N-Arachidonylglycine-d8 Inhibitor 98.1% Unkown
HY-10863S Anandamide-d8 99.90% Unkown
HY-162618 PSB-KK1445 Agonist 99.47% Unkown
HY-10863S1 Anandamide-d11 / Unkown
HY-RS05687 GPR18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-138121 PSB-KD107 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR18 VGNC VGNC:29574
Mus musculus GPR18 MGD MGI:107859
Felis catus GPR18 VGNC VGNC:67418
Rattus norvegicus GPR18 RGD RGD:1304889
Macaca mulatta GPR18 VGNC VGNC:73127
Canis familiaris GPR18 VGNC VGNC:41420
Others GPR18 NCBI