1. Gene
  2. NWD1 - NACHT and WD repeat domain containing 1 Gene

NWD1 - NACHT and WD repeat domain containing 1 Gene

Homo sapiens
Gene ID: 284434 | Gene type: protein coding

About NWD1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,719,847-16,817,963 (from NCBI)

This gene has 12 transcripts (splice variants), 111 orthologues and 26 paralogues. Biased expression in prostate (RPKM 3.7), brain (RPKM 1.6) and 6 other tissues.

Summary

The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate Cancer cell lines. Knocking down expression of this gene results in decreased Androgen Receptor protein levels, indicating that this gene may be important in modulating Androgen Receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

NWD1 Products(3)

mRNA Protein Name
NM_001007525.5 NP_001007526.3 NACHT domain- and WD repeat-containing protein 1 isoform 1
NM_001290355.3 NP_001277284.1 NACHT domain- and WD repeat-containing protein 1 isoform 2
NM_001347994.1 NP_001334923.1 NACHT domain- and WD repeat-containing protein 1 isoform 3
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
24681825 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24681825 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
24681825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NWD1 Protein Structure

NACHT

NACHT: NACHT domain (337 - 505)

WD40

WD40: WD domain, G-beta repeat (903 - 938)

WD40

WD40: WD domain, G-beta repeat (1384 - 1416)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1564 a.a.
Protein Preferred Names Protein Names

NACHT domain- and WD repeat-containing protein 1

NACHT and WD repeat domain-containing protein 1

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C2

NPC2

Niemann-Pick Disease Type C2

Niemann-Pick C2 Disease

Niemann-Pick Disease C2

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta NWD1 VGNC VGNC:84898
Mus musculus NWD1 MGD MGI:2442268
Canis familiaris NWD1 VGNC VGNC:44069
Bos taurus NWD1 VGNC VGNC:32373
Felis catus NWD1 VGNC VGNC:63933
Rattus norvegicus NWD1 RGD RGD:2321209