GPR31 - G protein-coupled receptor 31 Gene

Homo sapiens

Also known as HETER; HETER1; 12-HETER

Gene ID: 2853 | Gene type: protein coding

About GPR31

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:167,155,247-167,157,980 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 15 paralogues.

Summary

Enables G protein-coupled receptor activity and arachidonic acid binding activity. Involved in G protein-coupled receptor signaling pathway and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR31 Products(1)

mRNA	Protein	Name
NM_005299.3	NP_005290.2	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	21712392	GOA
enables arachidonate binding	IDA IDA: Inferred from direct assay	21712392	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28619714	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	21712392	GOA
involved in response to acidic pH	IDA IDA: Inferred from direct assay	31119277	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21712392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR31 Protein Structure

7tm_1

0
100
200
300
319 a.a.

Protein Preferred Names

Protein Names

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

12-(S)-HETE acid receptor

Related Diseases

Diseases

Alias

Ischemia

Acute Coronary Syndrome

Vulvar Dystrophy

Dystrophy Of Vulva

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05701	GPR31 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPR31	VGNC	VGNC:41430
Macaca mulatta	GPR31	VGNC	VGNC:104403
Mus musculus	GPR31	MGD	MGI:1354372
Rattus norvegicus	GPR31	RGD	RGD:1305187
Bos taurus	GPR31	VGNC	VGNC:29582

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