2. Gene
  3. GPR34 - G protein-coupled receptor 34 Gene

GPR34 - G protein-coupled receptor 34 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LYPSR1

Gene ID: 2857 | Gene type: protein coding

About GPR34

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:41,688,973-41,697,275 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues and 6 paralogues. Broad expression in placenta (RPKM 8.9), fat (RPKM 7.8) and 21 other tissues.

Summary

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

GPR34 Products(2)

mRNA Protein Name
NM_001097579.2 NP_001091048.1 probable G-protein coupled receptor 34
NM_005300.4 NP_005291.1 probable G-protein coupled receptor 34

GPR34 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (71 - 327)

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  • 381 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 34

Related Diseases

Diseases Alias
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset
Night Blindness

Nyctalopia
Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138501 GPR34 receptor antagonist 2 99.26% Unkown
HY-156815 YL-365 99.96% Unkown
HY-155417 GPR34 receptor antagonist 3 99.88% Unkown
HY-RS05704 GPR34 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR34 VGNC VGNC:73133
Rattus norvegicus GPR34 RGD RGD:1563681
Canis familiaris GPR34 VGNC VGNC:41431
Bos taurus GPR34 VGNC VGNC:29583
Felis catus GPR34 VGNC VGNC:82436
Mus musculus GPR34 MGD MGI:1346334