Mapk15 - mitogen-activated protein kinase 15 Gene

Rattus norvegicus

Also known as Erk7; ERK-8

Gene ID: 286997 | Gene type: protein coding

About Mapk15

Primary_assembly 7: 107,694,964-107,714,645 forward strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 197 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 39.2), Lung (RPKM 17.6) and 2 other tissues.

Summary

Predicted to enable MAP kinase activity and chromatin binding activity. Involved in several processes, including negative regulation of cellular macromolecule biosynthetic process; positive regulation of protein metabolic process; and response to estradiol. Located in nucleus. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Apr 2022]

Mapk15 Products(1)

mRNA	Protein	Name
NM_173331.2	NP_775453.1	mitogen-activated protein kinase 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9880541	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9891064	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12917323	RGD
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	12917323	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12917323	RGD
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	12917323	RGD
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	11287416	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9891064	RGD
involved in response to estradiol	IMP IMP: Inferred from mutant phenotype	12917323	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9880541	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk15 Protein Structure

STKc_MAPK15-like

0
100
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300
400
500
583 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 15

ERK-7	MAP kinase 15
MAPK 15	extracellular signal-regulated kinase 7
extracellular signal-regulated kinase 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-135906	CK2/ERK8-IN-1	≥99.0%	Unkown
HY-RS08110	MAPK15 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08111	Mapk15 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08112	Mapk15 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk15	NCBI	NCBI:225689

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