GPX5 - glutathione peroxidase 5 Gene

Homo sapiens

Also known as EGLP; GPx-5; GSHPx-5; HEL-S-75p

Gene ID: 2880 | Gene type: protein coding

About GPX5

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:28,525,881-28,534,955 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 373 orthologues and 7 paralogues. Restricted expression toward testis (RPKM 1.2).

Summary

This gene belongs to the Glutathione Peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this Enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]

GPX5 Products(2)

mRNA	Protein	Name
NM_001509.3	NP_001500.1	epididymal secretory glutathione peroxidase isoform 1 precursor
NM_003996.3	NP_003987.2	epididymal secretory glutathione peroxidase isoform 2 precursor

GPX5 Protein Structure

GSHPx

0
100
200
221 a.a.

Protein Preferred Names

Protein Names

epididymal secretory glutathione peroxidase

epididymal androgen-related protein

Related Diseases

Diseases

Alias

Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

Favism	Favism, Susceptibility To
Hemolytic Anemia, G6pd Deficient	Class I Glucose-6-Phosphate Dehydrogenase Deficiency
Class I G6pd Deficiency	Severe Hemolytic Anemia Due To G6pd Deficiency
Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency	NSHA
G6pd Deficient Hemolytic Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05768	GPX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPX5	RGD	RGD:69227
Bos taurus	GPX5	VGNC	VGNC:29620
Canis familiaris	GPX5	VGNC	VGNC:41464
Felis catus	GPX5	VGNC	VGNC:102434
Macaca mulatta	GPX5	VGNC	VGNC:73153
Mus musculus	GPX5	MGD	MGI:104886
Susscrofa domestica	GPX5	NCBI
Others	GPX5	NCBI

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