2. Gene
  3. MRPS28 - mitochondrial ribosomal protein S28 Gene

MRPS28 - mitochondrial ribosomal protein S28 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRPS35; COXPD47; HSPC007; MRP-S28; MRP-S35

Gene ID: 28957 | Gene type: protein coding

About MRPS28

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:79,918,717-80,030,259 (from NCBI)

This gene has 9 transcripts (splice variants), 190 orthologues and is associated with 1 phenotype. Ubiquitous expression in adrenal (RPKM 38.5), heart (RPKM 29.2) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]

MRPS28 Products(1)

mRNA Protein Name
NM_014018.3 NP_054737.1 28S ribosomal protein S28, mitochondrial
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial translation IMP
IMP: Inferred from mutant phenotype
30566640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS28 Protein Structure

MRP-S35

MRP-S35: Mitochondrial ribosomal protein MRP-S35 (75 - 177)

  • 0
  • 100
  • 187 a.a.
Protein Preferred Names Protein Names

28S ribosomal protein S28, mitochondrial

28S ribosomal protein S35, mitochondrial

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 47

COXPD47
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08683 MRPS28 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MRPS28 MGD MGI:1913480
Macaca mulatta MRPS28 VGNC VGNC:104466
Canis familiaris MRPS28 VGNC VGNC:43419
Felis catus MRPS28 VGNC VGNC:81709
Bos taurus MRPS28 VGNC VGNC:31668
Rattus norvegicus MRPS28 RGD RGD:1597461