2. Gene
  3. GRIK1 - glutamate ionotropic receptor kainate type subunit 1 Gene

GRIK1 - glutamate ionotropic receptor kainate type subunit 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5

Gene ID: 2897 | Gene type: protein coding

About GRIK1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,536,933-29,939,996 (from NCBI)

This gene has 8 transcripts (splice variants), 309 orthologues and 17 paralogues. Biased expression in adrenal (RPKM 3.8), brain (RPKM 1.9) and 2 other tissues.

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

GRIK1 Products(12)

mRNA Protein Name
NM_000830.6 NP_000821.1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor
NM_001320616.2 NP_001307545.1 glutamate receptor ionotropic, kainate 1 isoform 3 precursor
NM_001320618.2 NP_001307547.1 glutamate receptor ionotropic, kainate 1 isoform 4
NM_001320621.2 NP_001307550.1 glutamate receptor ionotropic, kainate 1 isoform 5
NM_001320630.2 NP_001307559.1 glutamate receptor ionotropic, kainate 1 isoform 6 precursor
NM_001330993.2 NP_001317922.1 glutamate receptor ionotropic, kainate 1 isoform 7 precursor
NM_001330994.2 NP_001317923.1 glutamate receptor ionotropic, kainate 1 isoform 8 precursor
NM_001393424.1 NP_001380353.1 glutamate receptor ionotropic, kainate 1 isoform 9
NM_001393425.1 NP_001380354.1 glutamate receptor ionotropic, kainate 1 isoform 10
NM_001393426.1 NP_001380355.1 glutamate receptor ionotropic, kainate 1 isoform 11
NM_001410706.1 NP_001397635.1 glutamate receptor ionotropic, kainate 1 isoform 12
NM_175611.3 NP_783300.1 glutamate receptor ionotropic, kainate 1 isoform 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
8589992 GOA
enables kainate selective glutamate receptor activity IDA
IDA: Inferred from direct assay
9335499 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIK1 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (55 - 394)

Lig_chan-Glu_bd

Lig_chan-Glu_bd: Ligated ion channel L-glutamate- and glycine-binding site (458 - 522)

Lig_chan

Lig_chan: Ligand-gated ion channel (576 - 846)

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  • 918 a.a.
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 1

GluK1(del_e2)

Related Diseases

Diseases Alias
Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe
Juvenile Absence Epilepsy

Epilepsy Juvenile Absence

Jae

Childhood Absence Epilepsy

Absence Epilepsy
Nondisjunction

Mosaicism, Chromosomal

Mixoploidy, Familial
Childhood Absence Epilepsy

Pyknolepsy

Petit Mal Epilepsy

Absence Seizures

Absence Seizure

Petit Mal Seizure

Absence Epilepsy, Childhood

Pykno-Epilepsy

Epilepsy, Absence

Absence Epilepsy

Pycnolepsy
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Adolescence-Adult Electroclinical Syndrome
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05798 GRIK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GRIK1 VGNC VGNC:53579
Felis catus GRIK1 VGNC VGNC:67467
Rattus norvegicus GRIK1 RGD RGD:2732
Canis familiaris GRIK1 VGNC VGNC:41486
Macaca mulatta GRIK1 VGNC VGNC:73277
Mus musculus GRIK1 MGD MGI:95814