2. Gene
  3. TMPRSS11E - transmembrane serine protease 11E Gene

TMPRSS11E - transmembrane serine protease 11E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DESC1; TMPRSS11E2

Gene ID: 28983 | Gene type: protein coding

About TMPRSS11E

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:68,447,463-68,497,604 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 338 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 128.8).

Summary

Predicted to enable serine-type peptidase activity. Involved in cognition. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMPRSS11E Products(1)

mRNA Protein Name
NM_014058.4 NP_054777.2 transmembrane protease serine 11E precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cognition IMP
IMP: Inferred from mutant phenotype
23227193 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS11E Protein Structure

SEA

SEA: SEA domain (49 - 156)

Trypsin

Trypsin: Trypsin (192 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

transmembrane protease serine 11E

serine protease DESC1

TMPRSS11E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TMPRSS11E Q9UL52 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra TMPRSS11E Q9UL52 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14766 TMPRSS11E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TMPRSS11E VGNC VGNC:78423
Rattus norvegicus TMPRSS11E RGD RGD:1561698
Mus musculus TMPRSS11E MGD MGI:3513175