ZCCHC4 - zinc finger CCHC-type containing 4 Gene

Homo sapiens

Also known as ZGRF4; HSPC052

Gene ID: 29063 | Gene type: protein coding

About ZCCHC4

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,312,774-25,370,383 (from NCBI)

This gene has 5 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.3) and 25 other tissues.

Summary

Enables S-adenosyl-L-methionine binding activity; rRNA (adenine-N6-)-methyltransferase activity; and zinc ion binding activity. Involved in positive regulation of translation and rRNA methylation. Located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ZCCHC4 Products(2)

mRNA	Protein	Name
NM_001318148.2	NP_001305077.1	rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 2
NM_024936.3	NP_079212.2	rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	31695039	GOA
enables rRNA (adenine-N6-)-methyltransferase activity	IDA IDA: Inferred from direct assay	30531910	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	31695039	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	30531910	GOA
involved in rRNA methylation	IDA IDA: Inferred from direct assay	30531910	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30531910	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	30531910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZCCHC4 Protein Structure

zf-GRF

N6-adenineMlase

0
100
200
300
400
513 a.a.

Protein Preferred Names

Protein Names

rRNA N6-adenosine-methyltransferase ZCCHC4

DHHC domain-containing zinc finger protein

Related Diseases

Diseases

Alias

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16005	ZCCHC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZCCHC4	VGNC	VGNC:79358
Rattus norvegicus	ZCCHC4	RGD	RGD:1311414
Canis familiaris	ZCCHC4	VGNC	VGNC:48570
Felis catus	ZCCHC4	VGNC	VGNC:67197
Bos taurus	ZCCHC4	VGNC	VGNC:37120
Mus musculus	ZCCHC4	MGD	MGI:1926046

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