PHPT1 - phosphohistidine phosphatase 1 Gene

Homo sapiens

Also known as PHP; PHP14; CGI-202; HSPC141; HEL-S-132P

Gene ID: 29085 | Gene type: protein coding

About PHPT1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,849,409-136,851,024 (from NCBI)

This gene has 6 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in heart (RPKM 26.6), prostate (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP Citrate Lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

PHPT1 Products(4)

mRNA	Protein	Name
NM_001135861.3	NP_001129333.1	14 kDa phosphohistidine phosphatase isoform 2
NM_001287342.2	NP_001274271.1	14 kDa phosphohistidine phosphatase isoform 4
NM_001287343.2	NP_001274272.1	14 kDa phosphohistidine phosphatase isoform 5
NM_014172.6	NP_054891.2	14 kDa phosphohistidine phosphatase isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	27924678	GOA
enables calcium channel inhibitor activity	IDA IDA: Inferred from direct assay	18796614	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein histidine phosphatase activity	IDA IDA: Inferred from direct assay	16219293	GOA
enables protein histidine phosphatase activity	IMP IMP: Inferred from mutant phenotype	18796614	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	18796614	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	27924678	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	19344975	GOA
involved in lamellipodium organization	IDA IDA: Inferred from direct assay	27924678	GOA
involved in negative regulation of ATP citrate synthase activity	IDA IDA: Inferred from direct assay	18656514	GOA
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18796614	GOA
involved in negative regulation of lyase activity	IDA IDA: Inferred from direct assay	20110805	GOA
involved in peptidyl-histidine dephosphorylation	IDA IDA: Inferred from direct assay	16219293	GOA
involved in positive regulation of cell motility	IMP IMP: Inferred from mutant phenotype	19344975	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	20501872	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	20501872	GOA
located in leading edge of lamellipodium	IDA IDA: Inferred from direct assay	27924678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHPT1 Protein Structure

Ocnus

0
100
125 a.a.

Protein Preferred Names

Protein Names

14 kDa phosphohistidine phosphatase

epididymis secretory sperm binding protein Li 132P

Recombinant PHPT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71769	PHPT1 Protein, Human (P.pastoris, His)	Q9NRX4-1 (M1-Y125)	≥95%
HY-P75975	PHPT1 Protein, Human (His)	Q9NRX4-1 (A2-Y125)	≥95%

Related Diseases

Diseases

Alias

Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome	Rh Disease
HDFNRH	Rh Fetomaternal Incompatibility
Rh-Null Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156029	IA1-8H2		/	Unkown
HY-RS10453	PHPT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PHPT1	RGD	RGD:1311355
Canis familiaris	PHPT1	VGNC	VGNC:44509
Felis catus	PHPT1	VGNC	VGNC:64153
Mus musculus	PHPT1	MGD	MGI:1922704
Bos taurus	PHPT1	VGNC	VGNC:32846
Others	PHPT1	NCBI

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