RANGRF - RAN guanine nucleotide release factor Gene

Homo sapiens

Also known as MOG1; HSPC165; HSPC236; RANGNRF

Gene ID: 29098 | Gene type: protein coding

About RANGRF

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,288,670-8,290,087 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues.

Summary

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac Sodium Channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

RANGRF Products(4)

mRNA	Protein	Name
NM_001177801.2	NP_001171272.1	ran guanine nucleotide release factor isoform B
NM_001177802.2	NP_001171273.1	ran guanine nucleotide release factor isoform C
NM_001330127.2	NP_001317056.1	ran guanine nucleotide release factor isoform D
NM_016492.5	NP_057576.2	ran guanine nucleotide release factor isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	11290418	GOA
enables sodium channel regulator activity	IDA IDA: Inferred from direct assay	18184654	GOA
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	23420830	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	18184654	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	29040603	GOA
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	18184654	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in regulation of bundle of His cell action potential	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of membrane depolarization	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of membrane depolarization	IMP IMP: Inferred from mutant phenotype	23420830	GOA
involved in regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21621375	GOA
involved in regulation of sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18184654	GOA
involved in regulation of sodium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21621375	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	23420830	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11290418	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11290418	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	23420830	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANGRF Protein Structure

Mog1

0
100
186 a.a.

Protein Preferred Names

Protein Names

ran guanine nucleotide release factor

MOG1 homolog

Related Diseases

Diseases

Alias

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Sick Sinus Syndrome

Sinus Node Dysfunction	Sinus Node Disease
Sinus Node Infection	Snd
Sss	Snd - [Sinus Node Dysfunction]
Sinoatrial Node Dysfunction	Sss - [Sick Sinus Syndrome]
Sick Sinus	Sick Sinus Tachycardia

Sinoatrial Node Disease

Sa Node	Sinuatrial Node
Sinus Node Dysfunction

Right Bundle Branch Block

Right Bundle Branch Block With Left Posterior Fascicular Block

Long Qt Syndrome 2

LQT2	Long Qt Syndrome, Acquired, Reduced Susceptibility To
Long Qt Syndrome 1/2	Long Qt Syndrome 2/3
Long Qt Syndrome 2/5	Long Qt Syndrome 2, Acquired, Susceptibility To
Long Qt Syndrome, Acquired, Reduced	Long Qt Syndrome Type 2
Long Qt Syndrome 2/9	Lqt1/2
Lqt2/3	Lqt2/5
Lqt2/9	Susceptibility To Acquired Long Qt Syndrome 2
Long Qt Syndrome-2	Qt Syndrome, Long, Type 2
Long Qt Syndrome 1-2	Long Qt Syndrome 2-3
Long Qt Syndrome 2-5	Long Qt Syndrome 9

Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt	Catecholamine-Induced Polymorphic Ventricular Tachycardia
Familial Polymorphic Ventricular Tachycardia	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Stress-Induced Polymorphic Ventricular Tachycardia
Bidirectional Tachycardia Induced By Catecholamine	Double Tachycardia Induced By Catecholamines
Polymorphic Catecholergic Ventricular Tachycardia	Syncopal Paroxysmal Tachycardia
Bidirectional Tachycardia Induced By Catecholamines	Fpvt
Bidirectional Ventricular Tachycardia Induced By Catecholamine	Polymorphic Ventricular Tachycardia Induced By Catecholamines
Ventricular Tachycardia, Catecholaminergic Polymorphic	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Familial Ventricular Tachycardia	Multifocal Pvcs
Multifocal Premature Ventricular Beats

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11651	RANGRF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RANGRF	VGNC	VGNC:33714
Mus musculus	RANGRF	MGD	MGI:1889073
Macaca mulatta	RANGRF	VGNC	VGNC:76503
Canis familiaris	RANGRF	VGNC	VGNC:45341
Rattus norvegicus	RANGRF	RGD	RGD:1563195

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