Oprl1 - opioid related nociceptin receptor 1 Gene

Rattus norvegicus

Also known as KOR3; OFQR; ORL1; Oprl; XOR1; KOR-3; LC132; MOR-C

Gene ID: 29256 | Gene type: protein coding

About Oprl1

Primary_assembly 3: 168,834,003-168,839,920 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 18 phenotypes. Restricted expression toward (RPKM 14.3).

Summary

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprl1 Products(3)

mRNA	Protein	Name
NM_001318947.1	NP_001305876.1	nociceptin receptor isoform 1x
NM_001318948.1	NP_001305877.1	nociceptin receptor isoform 2
NM_031569.4	NP_113757.1	nociceptin receptor isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15748148	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in conditioned place preference	IMP IMP: Inferred from mutant phenotype	21095077	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	11961051	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	12710984	RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15748148	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	10651151	RGD
involved in negative regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	16019191	RGD
involved in negative regulation of voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	15937148	RGD
involved in positive regulation of urine volume	IDA IDA: Inferred from direct assay	15010357	RGD
involved in regulation of locomotor rhythm	IMP IMP: Inferred from mutant phenotype	16310969	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12710984	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Oprl1 Protein Structure

7tmA_NOFQ_opioid_R

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

nociceptin receptor

ROR-C	kappa-type 3 opioid receptor
nociceptin receptor ORL1	opiate receptor-like 1
opioid receptor-like 1	orphanin FQ receptor
orphanin FQ receptor-a	orphanin FQ receptor-b
orphanin FQ receptor-e	peptide receptor
seven transmembrane G protein-coupled receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09803	OPRL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09804	Oprl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09805	Oprl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oprl1	NCBI	NCBI:4987

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