2. Gene
  3. OPRL1 - opioid related nociceptin receptor 1 Gene

OPRL1 - opioid related nociceptin receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; PNOCR

Gene ID: 4987 | Gene type: protein coding

About OPRL1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:64,080,082-64,100,643 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 202 orthologues and 17 paralogues. Broad expression in brain (RPKM 1.7), testis (RPKM 0.9) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

OPRL1 Products(13)

mRNA Protein Name
XM_047440154.1 XP_047296110.1 nociceptin receptor isoform X2
NM_182647.4 NP_872588.1 nociceptin receptor isoform 1
NM_001318853.2 NP_001305782.1 nociceptin receptor isoform 1x
XM_047440153.1 XP_047296109.1 nociceptin receptor isoform X1
NM_001318855.1 NP_001305784.1 nociceptin receptor isoform 3
NM_001200019.2 NP_001186948.1 nociceptin receptor isoform 1
XM_047440156.1 XP_047296112.1 nociceptin receptor isoform X3
XM_011528828.4 XP_011527130.1 nociceptin receptor isoform X1
XM_011528830.4 XP_011527132.1 nociceptin receptor isoform X4
NM_001318854.1 NP_001305783.1 nociceptin receptor isoform 2
NM_000913.6 NP_000904.1 nociceptin receptor isoform 1
XM_047440157.1 XP_047296113.1 nociceptin receptor isoform X4
XM_047440155.1 XP_047296111.1 nociceptin receptor isoform X3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
8137918 GOA
enables G protein-coupled receptor activity IPI
IPI: Inferred from physical interaction
10571060 GOA
enables nociceptin receptor activity IDA
IDA: Inferred from direct assay
10571060 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8137918 GOA
acts upstream of or within positive effect calcium-mediated signaling IDA
IDA: Inferred from direct assay
10571060 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IPI
IPI: Inferred from physical interaction
10571060 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8137918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPRL1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (68 - 319)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

nociceptin receptor

kappa-type 3 opioid receptor

kappa3-related opioid receptor

nociceptin/orphanin FQ receptor

opiate receptor-like 1

orphanin FQ receptor

Related Diseases

Diseases Alias
Pain Agnosia

Analgesia
Drug Dependence
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome
Opioid Abuse

Opioid-Related Disorders
Slate Pneumoconiosis

Schistosis
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Ivic Syndrome

Oculootoradial Syndrome

Radial Ray Defects, Hearing Impairment, External Ophthalmoplegia, And Thrombocytopenia

IVIC

Instituto Venezolano De Investigaciones Cientificas Syndrome

Oculo-Oto-Radial Syndrome

Oors
Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos
Psoriasis 7

PSORS7

Psoriasis 7, Susceptibility To

Psoriasis Susceptibility 7

Psoriasis

Psoriasis Vulgaris

Pv
Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09803 OPRL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09804 Oprl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09805 Oprl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris OPRL1 VGNC VGNC:44134
Rattus norvegicus OPRL1 RGD RGD:68438
Bos taurus OPRL1 VGNC VGNC:32440
Mus musculus OPRL1 MGD MGI:97440
Macaca mulatta OPRL1 VGNC VGNC:97110
Felis catus OPRL1 VGNC VGNC:68634