Tyms - thymidylate synthetase Gene

Rattus norvegicus

Gene ID: 29261 | Gene type: protein coding

About Tyms

Primary_assembly 9: 113,313,452-113,329,536 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 38 phenotypes. Biased expression in Thymus (RPKM 144.9), Spleen (RPKM 129.1) and 9 other tissues.

Summary

Enables several functions, including folic acid binding activity; protein homodimerization activity; and Thymidylate Synthase activity. Involved in several processes, including nucleobase-containing small molecule metabolic process; response to steroid hormone; and response to vitamin. Located in mitochondrion and nucleolus. Used to study urinary bladder Cancer. Biomarker of colorectal adenocarcinoma. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Tyms Products(1)

mRNA	Protein	Name
NM_019179.2	NP_062052.1	thymidylate synthase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables folic acid binding	IDA IDA: Inferred from direct assay	7537805	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	9894005	RGD
enables mRNA binding	IPI IPI: Inferred from physical interaction	9891091	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9894005	RGD
enables thymidylate synthase activity	IDA IDA: Inferred from direct assay	9894005	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cartilage development	IEP IEP: Inferred from expression pattern	3471366	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19628084	RGD
involved in dTMP biosynthetic process	IDA IDA: Inferred from direct assay	9894005	RGD
involved in developmental growth	IEP IEP: Inferred from expression pattern	7471094	RGD
involved in intestinal epithelial cell maturation	IEP IEP: Inferred from expression pattern	1260861	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	2707640	RGD
involved in pyrimidine nucleobase metabolic process	IEP IEP: Inferred from expression pattern	9524100	RGD
involved in regulation of translation	IDA IDA: Inferred from direct assay	26315778	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	9524100	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	9305788	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	9528665	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	2707640	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	9683817	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	9635926	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	8781506	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	10395942	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	7686361	RGD
involved in tetrahydrofolate metabolic process	IEP IEP: Inferred from expression pattern	7503782	RGD
involved in uracil metabolic process	IEP IEP: Inferred from expression pattern	2043679	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tyms Protein Structure

PTZ00164

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

thymidylate synthase

TSase

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163538	TYM-3-98		/	Unkown
HY-RS15304	TYMS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15305	Tyms Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15306	Tyms Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N3764	Diosbulbin C	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tyms	NCBI	NCBI:7298

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