Prkce - protein kinase C, epsilon Gene

Rattus norvegicus

Also known as Pkce

Gene ID: 29340 | Gene type: protein coding

About Prkce

Primary_assembly 6: 7,965,048-8,451,719 reverse strand.mRatBN7.2:CM026979.1

This gene has 3 transcripts (splice variants), 312 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 183.2), Heart (RPKM 82.1) and 9 other tissues.

Summary

Enables several functions, including SH3 domain binding activity; protein kinase C activity; and protein kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Located in Golgi membrane; T-tubule; and cytosol. Is active in glutamatergic synapse; neuromuscular junction; and presynaptic cytosol. Used to study hypertension. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Prkce Products(1)

mRNA	Protein	Name
NM_017171.2	NP_058867.2	protein kinase C epsilon type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	17084383	RGD
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	22619279	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9360998	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17084383	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	15652511	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20383739	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to platelet-derived growth factor stimulus	IMP IMP: Inferred from mutant phenotype	22619279	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11562372	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20383739	RGD
involved in negative regulation of mitochondrial calcium ion concentration	IMP IMP: Inferred from mutant phenotype	20383739	RGD
involved in negative regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	20383739	RGD
involved in negative regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	20383739	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	26625935	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26625935	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	9360998	RGD
located in T-tubule	IDA IDA: Inferred from direct assay	19525381	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8481800	RGD
is active in neuromuscular junction	EXP EXP: Inferred from Experiment	26625935	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	26625935	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	8481800	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkce Protein Structure

C2_PKC_epsilon

C1_nPKC_epsilon-like_rpt1

C1_nPKC_epsilon-like_rpt2

STKc_nPKC_epsilon

0
200
400
600
737 a.a.

Protein Preferred Names

Protein Names

protein kinase C epsilon type

nPKC-epsilon

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11125	PRKCE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11126	Prkce Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11127	Prkce Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkce	NCBI	NCBI:5581

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