Esrra - estrogen related receptor, alpha Gene

Rattus norvegicus

Also known as Errra; ERRalpha

Gene ID: 293701 | Gene type: protein coding

About Esrra

Primary_assembly 1: 204,104,101-204,114,268 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 175 orthologues, 8 paralogues and is associated with 15 phenotypes. Biased expression in Heart (RPKM 313.6), Muscle (RPKM 294.8) and 9 other tissues.

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including regulation of osteoblast differentiation; regulation of osteoclast differentiation; and response to estradiol. Located in nucleus. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Esrra Products(1)

mRNA	Protein	Name
NM_001008511.2	NP_001008511.2	steroid hormone receptor ERR1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20215575	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	17170100	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17170100	RGD
involved in positive regulation of cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	20215575	RGD
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11381083	RGD
involved in regulation of ossification	IMP IMP: Inferred from mutant phenotype	12193582	RGD
involved in regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	11381083	RGD
involved in regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	12193582	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15458797	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrra Protein Structure

NR_DBD_ERR

NR_LBD_ERR

0
100
200
300
422 a.a.

Protein Preferred Names

Protein Names

steroid hormone receptor ERR1

ERR-alpha	nuclear receptor subfamily 3 group B member 1
orphan nuclear receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04537	ESRRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04538	Esrra Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04539	Esrra Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esrra	NCBI	NCBI:2101

Name
Email *

	Sorry, but the email address you supplied was invalid.