Pak3 - p21 (RAC1) activated kinase 3 Gene

Rattus norvegicus

Also known as beta-PAK

Gene ID: 29433 | Gene type: protein coding

About Pak3

Primary_assembly X: 107,260,898-107,368,314 forward strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 213 orthologues, 36 paralogues and is associated with 9 phenotypes. Biased expression in Brain (RPKM 136.9), Testes (RPKM 64.9) and 2 other tissues.

Summary

Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pak3 Products(1)

mRNA	Protein	Name
NM_019210.2	NP_062083.1	serine/threonine-protein kinase PAK 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IDA IDA: Inferred from direct assay	7559638	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	7559638	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9823899	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	12890786	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	18481281	RGD
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	23818969	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12890786	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9823899	RGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23818969	RGD
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15574732	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	12890786	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak3 Protein Structure

PBD

STKc_PAK3

0
100
200
300
400
500
580 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 3

PAK-3	p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3	p21-activated kinase 3
p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related)	p65-PAK

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Phase 1
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15542A	FRAX597	Inhibitor	99.79%	Unkown
HY-15542B	FRAX486	Inhibitor	98.01%	Unkown
HY-143490	PAK4-IN-2	Inhibitor	99.78%	Unkown
HY-146786	ZMF-10	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak3	NCBI	NCBI:5063

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