Rgs4 - regulator of G-protein signaling 4 Gene

Rattus norvegicus

Gene ID: 29480 | Gene type: protein coding

About Rgs4

Primary_assembly 13: 81,936,775-81,943,068 reverse strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 197 orthologues, 22 paralogues and is associated with 13 phenotypes. Biased expression in Brain (RPKM 76.9), Adrenal (RPKM 271.2) and 4 other tissues.

Summary

Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including regulation of ion transport; regulation of signal transduction; and response to alkaloid. Located in cytosol; nucleus; and plasma membrane. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Apr 2022]

Rgs4 Products(1)

mRNA	Protein	Name
NM_017214.2	NP_058910.1	regulator of G-protein signaling 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	9108480	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	20530129	RGD
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10942773	RGD
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	9430692	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17084383	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dorsal root ganglion development	IEP IEP: Inferred from expression pattern	14550772	RGD
involved in negative regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9918533	RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development	IDA IDA: Inferred from direct assay	9918533	RGD
involved in negative regulation of dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	21896332	RGD
involved in negative regulation of glycine import across plasma membrane	IMP IMP: Inferred from mutant phenotype	21798518	RGD
involved in negative regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	24421355	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	9430692	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17220354	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	25844489	RGD
involved in regulation of actin filament organization	IDA IDA: Inferred from direct assay	9918533	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	16699510	RGD
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	11906535	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	26321241	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	17632279	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	28736108	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	9108480	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rgs4 Protein Structure

RGS_RGS4

0
100
205 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 4

RGP4

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13509	CCG-50014	Inhibitor	99.42%	Unkown
HY-U00431	CCG 203769	Inhibitor	99.76%	Unkown
HY-70074	CCG-63802	Inhibitor	98.83%	Unkown
HY-110054	CCG-2046	Inhibitor	/	Unkown
HY-122251	CCG-4986	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgs4	NCBI	NCBI:5999

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