Map2k5 - mitogen activated protein kinase kinase 5 Gene

Rattus norvegicus

Also known as Mek5

Gene ID: 29568 | Gene type: protein coding

About Map2k5

Primary_assembly 8: 63,625,221-63,851,983 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 9 phenotypes.

Summary

Enables ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of gene expression. Located in cytosol and nucleus. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 Products(2)

mRNA	Protein	Name
NM_001033987.1	NP_001029159.1	dual specificity mitogen-activated protein kinase kinase 5 isoform a
NM_017246.2	NP_058942.1	dual specificity mitogen-activated protein kinase kinase 5 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	7499418	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	7499418	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK5 cascade	IMP IMP: Inferred from mutant phenotype	15631999	RGD
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in cellular response to growth factor stimulus	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20724525	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15623435	RGD
involved in positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	15631999	RGD
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20551324	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	7499418	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5	MAPK/ERK kinase 5
MAPKK 5	MEK 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k5	NCBI	NCBI:5607

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