MAP2K5 - mitogen-activated protein kinase kinase 5 Gene

Homo sapiens

Also known as MEK5; MAPKK5; PRKMK5; HsT17454

Gene ID: 5607 | Gene type: protein coding

About MAP2K5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:67,542,703-67,807,114 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 2.0), testis (RPKM 1.9) and 25 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

MAP2K5 Products(10)

mRNA	Protein	Name
XM_011521788.4	XP_011520090.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X2
XM_017022414.3	XP_016877903.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X3
NM_002757.4	NP_002748.1	dual specificity mitogen-activated protein kinase kinase 5 isoform B
XM_011521787.4	XP_011520089.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X1
XM_047432856.1	XP_047288812.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X4
NM_145162.1
NM_145160.3	NP_660143.1	dual specificity mitogen-activated protein kinase kinase 5 isoform A
NM_001206804.2	NP_001193733.1	dual specificity mitogen-activated protein kinase kinase 5 isoform C
NM_145161.1
XR_007064474.1

MAP2K5 Protein Structure

PB1

Pkinase

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5	MAP kinase kinase MEK5b
MAPK/ERK kinase 5	MAPKK 5
MEK 5

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP2K5	RGD	RGD:61890
Mus musculus	MAP2K5	MGD	MGI:1346345
Felis catus	MAP2K5	VGNC	VGNC:104488
Canis familiaris	MAP2K5	VGNC	VGNC:42963
Macaca mulatta	MAP2K5	VGNC	VGNC:81455
Bos taurus	MAP2K5	VGNC	VGNC:31186

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