TGFBR1 - transforming growth factor, beta receptor 1 Gene

Rattus norvegicus

Also known as Alk5; Skr4; Tgfr-1; tbetaR-I

Gene ID: 29591 | Gene type: protein coding

About TGFBR1

Primary_assembly 5: 61,653,233-61,710,777 forward strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 236 orthologues, 11 paralogues and is associated with 40 phenotypes. Biased expression in Kidney (RPKM 195.8), Thymus (RPKM 187.5) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including embryo implantation; regulation of pri-miRNA transcription by RNA polymerase II; and response to prostaglandin E. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder Cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

TGFBR1 Products(1)

mRNA	Protein	Name
NM_012775.2	NP_036907.2	TGF-beta receptor type-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	17505012	RGD
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	8272871	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	8272871	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16617054	RGD
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	8272871	RGD
enables transforming growth factor beta receptor activity, type I	IMP IMP: Inferred from mutant phenotype	8272871	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17347560	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	9699514	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	12815632	RGD
involved in embryo implantation	IEP IEP: Inferred from expression pattern	16426643	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	10835329	RGD
involved in negative regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17450384	RGD
involved in negative regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	21704009	RGD
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	21704009	RGD
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	8272871	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17505012	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	16682418	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	12097811	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18760335	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12890451	RGD
involved in response to prostaglandin E	IEP IEP: Inferred from expression pattern	12890451	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16682418	RGD
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8272871	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10590020	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10590020	RGD
located in caveola	IDA IDA: Inferred from direct assay	17878231	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	17878231	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16617054	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFBR1 Protein Structure

Activin_recp

TGF_beta_GS

STKc_TGFbR1_ACVR1b_ACVR1c

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

TGF-beta receptor type-1

TGF-beta receptor type I	TGF-beta receptor type-1-like
TGF-beta type I receptor	activin receptor-like kinase 5
serine/threonine-protein kinase receptor R4	transforming growth factor, beta receptor I
transforming growth factor-beta receptor type I

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136244	PF-06952229	Inhibitor	99.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123900	AZ12799734	Inhibitor	98.07%	Unkown
HY-122856	AZ12601011	Inhibitor	99.88%	Unkown
HY-164793	TGFBR1-IN-2		/	Unkown
HY-129171	TGFBR1-IN-1	Inhibitor	/	Unkown
HY-RS14444	TGFBR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14445	Tgfbr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14446	TGFBR1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TGFBR1	NCBI	NCBI:7046
Mus musculus	TGFBR1	NCBI	NCBI:21812

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