P2ry2 - purinergic receptor P2Y2 Gene

Rattus norvegicus

Also known as P2Y2

Gene ID: 29597 | Gene type: protein coding

About P2ry2

Primary_assembly 1: 155,351,165-155,367,632 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 201 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Liver (RPKM 266.1), Muscle (RPKM 112.6) and 7 other tissues.

Summary

Enables A1 Adenosine Receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including positive regulation of penile erection; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with early endosome; lysosome; and mitochondrion. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2022]

P2ry2 Products(1)

mRNA	Protein	Name
NM_017255.2	NP_058951.2	P2Y purinoceptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables A1 adenosine receptor binding	IPI IPI: Inferred from physical interaction	11390975	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	11557527	RGD
enables G protein-coupled UTP receptor activity	IDA IDA: Inferred from direct assay	15924261	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11390975	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel diameter maintenance	IDA IDA: Inferred from direct assay	12730558	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	19317852	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18689605	RGD
involved in cellular response to purine-containing compound	IEP IEP: Inferred from expression pattern	16831297	RGD
involved in in utero embryonic development	IEP IEP: Inferred from expression pattern	14517997	RGD
NOT involved in microglial cell activation	IMP IMP: Inferred from mutant phenotype	11245682	RGD
involved in negative regulation of ossification	IDA IDA: Inferred from direct assay	12210747	RGD
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	17947675	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	19155635	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	15379893	RGD
involved in positive regulation of penile erection	IDA IDA: Inferred from direct assay	19303093	RGD
involved in positive regulation of prostaglandin secretion	IDA IDA: Inferred from direct assay	15840771	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	11934835	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	14714568	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11557527	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11557527	RGD
located in early endosome	IDA IDA: Inferred from direct assay	15924261	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16000618	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16000618	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	16000618	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry2 Protein Structure

7tmA_P2Y2

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 2

ATP receptor	P2U purinoceptor 1
P2U1	P2Y ATP receptor 2
purinergic receptor P2Y, G-protein coupled, 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09928	P2RY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09929	P2ry2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09930	P2ry2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2ry2	NCBI	NCBI:5029

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