Ntrk3 - neurotrophic receptor tyrosine kinase 3 Gene

Rattus norvegicus

Also known as trkC

Gene ID: 29613 | Gene type: protein coding

About Ntrk3

Primary_assembly 1: 132,132,849-132,503,286 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 271 orthologues, 54 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 154.8), Adrenal (RPKM 34.) and 6 other tissues.

Summary

Enables GPI-linked Ephrin Receptor activity. Involved in several processes, including cellular response to retinoic acid; generation of neurons; and regulation of synapse assembly. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach Cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk3 Products(3)

mRNA	Protein	Name
NM_019248.2	NP_062121.1	NT-3 growth factor receptor isoform 3 precursor
NM_001270656.1	NP_001257585.1	NT-3 growth factor receptor isoform 1 precursor
NM_001270655.1	NP_001257584.1	NT-3 growth factor receptor isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GPI-linked ephrin receptor activity	IDA IDA: Inferred from direct assay	19036963	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17341134	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	10027563	RGD
involved in cochlea development	IEP IEP: Inferred from expression pattern	10494076	RGD
involved in negative regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12075995	RGD
involved in neuron fate specification	IMP IMP: Inferred from mutant phenotype	15247919	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	12075995	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	8494647	RGD
involved in postsynaptic density assembly	EXP EXP: Inferred from Experiment	21262467	RGD
involved in postsynaptic density assembly	IDA IDA: Inferred from direct assay	21262467	RGD
involved in regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	12075995	RGD
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	21262467	RGD
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	21262467	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	17532148	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	14557907	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	11743997	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	21262467	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21262467	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21262467	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	21262467	RGD
is active in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	21262467	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk3 Protein Structure

LRRNT

LRR_8

LRR_1

TPKR_C2

IgI_TrKABC_d5

PTKc_TrkC

0
200
400
600
800
864 a.a.

Protein Preferred Names

Protein Names

NT-3 growth factor receptor

GP145-TrkC	neural receptor protein-tyrosine kinase (trkC)
neurotrophic tyrosine kinase, receptor, type 3	trk-C
trkC tyrosine kinase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09634	NTRK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09635	Ntrk3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09636	Ntrk3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk3	NCBI	NCBI:4916

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