2. Gene
  3. GUCY1A2 - guanylate cyclase 1 soluble subunit alpha 2 Gene

GUCY1A2 - guanylate cyclase 1 soluble subunit alpha 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GC-SA2; GUC1A2

Gene ID: 2977 | Gene type: protein coding

About GUCY1A2

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:106,674,019-107,018,476 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 17 paralogues. Broad expression in endometrium (RPKM 8.8), placenta (RPKM 7.4) and 15 other tissues.

Summary

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the Guanylate Cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A2 Products(2)

mRNA Protein Name
NM_000855.3 NP_000846.1 guanylate cyclase soluble subunit alpha-2 isoform 2
NM_001256424.2 NP_001243353.1 guanylate cyclase soluble subunit alpha-2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24550280 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCY1A2 Protein Structure

HNOB

HNOB: Haem-NO-binding (150 - 274)

HNOBA

HNOBA: Heme NO binding associated (314 - 506)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (513 - 683)

  • 0
  • 200
  • 400
  • 600
  • 732 a.a.
Protein Preferred Names Protein Names

guanylate cyclase soluble subunit alpha-2

GCS-alpha-2

GUCY1A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GUCY1A2 P33402 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
GUCY1A2 P33402 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05919 GUCY1A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GUCY1A2 MGD MGI:2660877
Bos taurus GUCY1A2 VGNC VGNC:29719
Macaca mulatta GUCY1A2 VGNC VGNC:82154
Canis familiaris GUCY1A2 VGNC VGNC:41566
Felis catus GUCY1A2 VGNC VGNC:103035
Rattus norvegicus GUCY1A2 RGD RGD:621655