UQCR10 - ubiquinol-cytochrome c reductase, complex III subunit X Gene

Homo sapiens

Also known as QCR9; UCRC; HSPC051; HSPC119; HSPC151; UCCR7.2

Gene ID: 29796 | Gene type: protein coding

About UQCR10

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,767,369-29,770,413 (from NCBI)

This gene has 2 transcripts (splice variants) and 171 orthologues. Ubiquitous expression in heart (RPKM 65.5), colon (RPKM 45.4) and 25 other tissues.

Summary

UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

UQCR10 Products(2)

mRNA	Protein	Name
NM_001003684.2	NP_001003684.1	cytochrome b-c1 complex subunit 9 isoform b
NM_013387.4	NP_037519.2	cytochrome b-c1 complex subunit 9 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35101990	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCR10 Protein Structure

UCR_UQCRX_QCR9

0
63 a.a.

Protein Preferred Names

Protein Names

cytochrome b-c1 complex subunit 9

cytochrome C1, nonheme 7kDa protein

Related Diseases

Diseases

Alias

Mitochondrial Complex Iii Deficiency

Complex 3 Mitochondrial Respiratory Chain Deficiency	Isolated Coq-Cytochrome C Reductase Deficiency
Ubiquinone-Cytochrome C Oxidoreductase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15496	UQCR10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UQCR10	MGD	MGI:1913402
Rattus norvegicus	UQCR10	RGD	RGD:1595126
Felis catus	UQCR10	VGNC	VGNC:80544
Bos taurus	UQCR10	VGNC	VGNC:36693
Canis familiaris	UQCR10	VGNC	VGNC:48162

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