2. Gene
  3. REPIN1 - replication initiator 1 Gene

REPIN1 - replication initiator 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AP4; RIP60; ZNF464; Zfp464

Gene ID: 29803 | Gene type: protein coding

About REPIN1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,368,096-150,374,039 (from NCBI)

This gene has 19 transcripts (splice variants) and 81 orthologues. Ubiquitous expression in colon (RPKM 20.6), spleen (RPKM 16.1) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of glucose import and regulation of fatty acid transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

REPIN1 Products(35)

mRNA Protein Name
NM_001099695.2 NP_001093165.1 replication initiator 1 isoform 3
NM_001099696.3 NP_001093166.1 replication initiator 1 isoform 1
NM_001362745.2 NP_001349674.1 replication initiator 1 isoform 3
NM_001362746.2 NP_001349675.1 replication initiator 1 isoform 1
NM_001362747.2 NP_001349676.1 replication initiator 1 isoform 1
NM_001388037.1 NP_001374966.1 replication initiator 1 isoform 4
NM_001388038.1 NP_001374967.1 replication initiator 1 isoform 3
NM_001388039.1 NP_001374968.1 replication initiator 1 isoform 3
NM_001388040.1 NP_001374969.1 replication initiator 1 isoform 3
NM_001388041.1 NP_001374970.1 replication initiator 1 isoform 5
NM_001388042.1 NP_001374971.1 replication initiator 1 isoform 5
NM_001388043.1 NP_001374972.1 replication initiator 1 isoform 5
NM_001388044.1 NP_001374973.1 replication initiator 1 isoform 5
NM_001388045.1 NP_001374974.1 replication initiator 1 isoform 5
NM_001388046.1 NP_001374975.1 replication initiator 1 isoform 1
NM_001388047.1 NP_001374976.1 replication initiator 1 isoform 1
NM_001388048.1 NP_001374977.1 replication initiator 1 isoform 1
NM_001388049.1 NP_001374978.1 replication initiator 1 isoform 1
NM_001388050.1 NP_001374979.1 replication initiator 1 isoform 1
NM_001388051.1 NP_001374980.1 replication initiator 1 isoform 1
NM_001388052.1 NP_001374981.1 replication initiator 1 isoform 1
NM_001388053.1 NP_001374982.1 replication initiator 1 isoform 1
NM_001388054.1 NP_001374983.1 replication initiator 1 isoform 1
NM_001388055.1 NP_001374984.1 replication initiator 1 isoform 1
NM_001388056.1 NP_001374985.1 replication initiator 1 isoform 1
NM_001388057.1 NP_001374986.1 replication initiator 1 isoform 1
NM_001388058.1 NP_001374987.1 replication initiator 1 isoform 1
NM_001388059.1 NP_001374988.1 replication initiator 1 isoform 1
NM_001388060.1 NP_001374989.1 replication initiator 1 isoform 1
NM_001388061.1 NP_001374990.1 replication initiator 1 isoform 1
NM_001388062.1 NP_001374991.1 replication initiator 1 isoform 1
NM_001388063.1 NP_001374992.1 replication initiator 1 isoform 1
NM_001388064.1 NP_001374993.1 replication initiator 1 isoform 1
NM_001388065.1 NP_001374994.1 replication initiator 1 isoform 1
NM_013400.4 NP_037532.2 replication initiator 1 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
2174103 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REPIN1 Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (86 - 107)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (116 - 138)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (146 - 168)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (177 - 199)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (250 - 275)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (279 - 303)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (390 - 413)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (417 - 441)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (445 - 470)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (474 - 497)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (501 - 525)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (543 - 565)

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  • 567 a.a.
Protein Preferred Names Protein Names

replication initiator 1

60 kDa origin-specific DNA-binding protein

Related Diseases

Diseases Alias
Cyclosporiasis

Cyclosporosis

Cyclospora Infection
Crouzon Syndrome With Acanthosis Nigricans

Crouzon Syndrome-Acanthosis Nigricans Syndrome

CAN

Crouzonodermoskeletal Syndrome

Crouzon-Dermoskeletal Syndrome

Crouzon, With Acanthosis Nigricans Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11844 REPIN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus REPIN1 RGD RGD:1549707
Felis catus REPIN1 VGNC VGNC:64572
Mus musculus REPIN1 MGD MGI:1889817
Macaca mulatta REPIN1 VGNC VGNC:76758
Canis familiaris REPIN1 VGNC VGNC:51824
Bos taurus REPIN1 VGNC VGNC:33868