1. Gene
  2. STRN4 - striatin 4 Gene

STRN4 - striatin 4 Gene

Homo sapiens

Also known as ZIN; PPP2R6C; zinedin

Gene ID: 29888 | Gene type: protein coding

About STRN4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,719,511-46,746,450 (from NCBI)

This gene has 24 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in testis (RPKM 42.4), spleen (RPKM 16.0) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity and protein Phosphatase 2A binding activity. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN4 Products(2)

mRNA Protein Name
NM_001039877.2 NP_001034966.1 striatin-4 isoform 2
NM_013403.3 NP_037535.2 striatin-4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables armadillo repeat domain binding IPI
IPI: Inferred from physical interaction
18502210 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
18782753 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
32640226 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
32640226 GOA
Cellular Component GO Annotation Evidence Reference Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRN4 Protein Structure

Striatin

Striatin: Striatin family (64 - 196)

WD40

WD40: WD domain, G-beta repeat (428 - 466)

WD40

WD40: WD domain, G-beta repeat (482 - 519)

WD40

WD40: WD domain, G-beta repeat (537 - 572)

WD40

WD40: WD domain, G-beta repeat (669 - 707)

WD40

WD40: WD domain, G-beta repeat (721 - 752)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
Protein Preferred Names Protein Names

striatin-4

protein phosphatase 2 regulatory subunit B'''gamma

STRN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STRN4 Q9NRL3 JUN Homo sapiens P05412
TAP
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Muscular Dystrophy-Dystroglycanopathy , Type C, 5

Lgmd2i

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2i

MDDGC5

Limb-Girdle Muscular Dystrophy Due To Fkrp Deficiency

Limb-Girdle Muscular Dystrophy Type 2i

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 9

Lgmdr9

Muscular Dystrophy, Limb-Girdle, Type 2i

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Frkp-Related

Fkrp-Related Limb-Girdle Muscular Dystrophy R9

Fkrp-Related Lgmd R9

Lgmd Due To Fkrp Deficiency

Lgmd Type 2i

Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Frkp-Related

Muscular Dystrophy Limb-Girdle Type 2i

Muscular Dystrophy-Dystroglycanopathy Type C 5

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C5

Dystrophy, Muscular, Limb-Girdle, Type 2i

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris STRN4 VGNC VGNC:46947
Felis catus STRN4 VGNC VGNC:65803
Bos taurus STRN4 VGNC VGNC:35426
Rattus norvegicus STRN4 RGD RGD:1307030
Macaca mulatta STRN4 VGNC VGNC:78128
Mus musculus STRN4 MGD MGI:2142346