LRP12 - LDL receptor related protein 12 Gene

Homo sapiens

Also known as ST7; MIG13A

Gene ID: 29967 | Gene type: protein coding

About LRP12

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,489,236-104,589,258 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 9.3), brain (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many Cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

LRP12 Products(2)

mRNA	Protein	Name
NM_001135703.3	NP_001129175.1	low-density lipoprotein receptor-related protein 12 isoform b precursor
NM_013437.5	NP_038465.1	low-density lipoprotein receptor-related protein 12 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12809483	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within neuron migration	IDA IDA: Inferred from direct assay	26639854	GOA
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	26639854	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12809483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP12 Protein Structure

CUB

Ldl_recept_a

CUB

Ldl_recept_a

0
200
400
600
800
859 a.a.

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 12

LDLR-related protein 12

Recombinant LRP12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70946	LRP-12 Protein, Human (HEK293, His)	Q9Y561-1 (E33-I488)	≥95%

Related Diseases

Diseases

Alias

Oculopharyngodistal Myopathy 1

Oculopharyngodistal Myopathy	Opdm
OPDM1	Faciooculolaryngopharyngeal Myopathy With Distal And Respiratory Involvement
Folp-Dr	Oculopharyngeal Distal Myopathy
Myopathy, Oculopharyngodistal	Myopathy, Oculopharyngodistal, Type 1

Neuronal Intranuclear Inclusion Disease

NIID	Neuronal Intranuclear Hyaline Inclusion Disease

Retinitis Pigmentosa 62

RP62	Retinitis Pigmentosa, Type 62

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Fatal Infantile Hypertonic Myofibrillar Myopathy

Myopathy

Muscular Diseases

Myopathies

Epilepsy, Familial Adult Myoclonic, 3

FAME3	Fcmte3
Cortical Myoclonic Tremor With Epilepsy, Familial, 3	Familial Adult Myoclonic Epilepsy 3
Familial Cortical Myoclonic Tremor And Epilepsy 3	Epilepsy, Myoclonic, Familial Adult, Type 3

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07795	LRP12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LRP12	VGNC	VGNC:59046
Mus musculus	LRP12	MGD	MGI:2443132
Rattus norvegicus	LRP12	RGD	RGD:1304943
Macaca mulatta	LRP12	VGNC	VGNC:74410
Bos taurus	LRP12	VGNC	VGNC:30989
Others	LRP12	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.