2. Gene
  3. Tbk1 - TANK-binding kinase 1 Gene

Tbk1 - TANK-binding kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 299827 | Gene type: protein coding

About Tbk1

Primary_assembly 7: 57,077,830-57,110,892 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 9 phenotypes. Biased expression in Spleen (RPKM 24.3), Thymus (RPKM 158.6) and 9 other tissues.

Summary

Predicted to enable several functions, including identical protein binding activity; phosphoprotein binding activity; and protein Phosphatase binding activity. Predicted to be involved in several processes, including positive regulation of defense response; protein phosphorylation; and regulation of gene expression. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbk1 Products(1)

mRNA Protein Name
NM_001106786.1 NP_001100256.1 serine/threonine-protein kinase TBK1

Tbk1 Protein Structure

STKc_TBK1

STKc_TBK1: cd13988 (14 - 329)

Ubl_TBK1

Ubl_TBK1: cd17127 (307 - 384)

TBK1_CCD1

TBK1_CCD1: pfam18394 (399 - 654)

TBK1_C

TBK1_C: cd21954 (677 - 723)

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  • 729 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase TBK1

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0713 Amlexanox Inhibitor 99.74% Unkown
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10514 BX795 Inhibitor 99.84% Unkown
HY-111941 GSK8612 Inhibitor 99.62% Unkown
HY-13018 MRT67307 Inhibitor 99.34% Unkown
HY-133117 BAY-985 Inhibitor 99.88% Unkown
HY-152237 TBK1-IN-1 Inhibitor 99.91% Unkown
HY-12453 TBK1/IKKε-IN-2 Inhibitor 98.09% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% Unkown
HY-14682 GSK319347A Inhibitor 99.40% Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-133117A (Rac)-BAY-985 Inhibitor / Unkown
HY-U00457 TBK1/IKKε-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbk1 NCBI NCBI:29110