HABP2 - hyaluronan binding protein 2 Gene

Homo sapiens

Also known as FSAP; HABP; PHBP; HGFAL; NMTC5

Gene ID: 3026 | Gene type: protein coding

About HABP2

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:113,550,831-113,589,602 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 158.0), gall bladder (RPKM 23.3) and 1 other tissue.

Summary

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive Peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid Cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

HABP2 Products(2)

mRNA	Protein	Name
NM_001177660.3	NP_001171131.1	hyaluronan-binding protein 2 isoform 2
NM_004132.5	NP_004123.1	hyaluronan-binding protein 2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	11217080	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	11217080	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HABP2 Protein Structure

EGF

Kringle

Trypsin

0
100
200
300
400
500
560 a.a.

Protein Preferred Names

Protein Names

hyaluronan-binding protein 2

factor VII activating protein

Recombinant HABP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70832	HABP2 Protein, Human (HEK293, His)	Q14520-1 (F24-Q279)	≥95%

Related Diseases

Diseases

Alias

Thyroid Cancer, Nonmedullary, 5

NMTC5	Thyroid Cancer, Non-Medullary, 5
Thyroid Cancer, Nonmedullary, 5, Susceptibility To	Cancer, Thyroid, Nonmedullary, Type 5

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Familial Papillary Or Follicular Thyroid Carcinoma

Fnmtc	Familial Pure Nonmedullary Thyroid Carcinoma
Familial Nonmedullary Thyroid Gland Carcinoma

Carotid Stenosis

Carotid Artery Stenosis

Stenosis, Carotid Artery

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Palmoplantar Keratoderma, Punctate Type Ia

Keratosis Palmoplantaris Papulosa	Punctate Palmoplantar Keratoderma Type I
Ppkp1	Keratodermia Palmoplantaris Papulosa, Buschke-Fischer-Brauer Type
PPKP1A	Kppp1
Punctate Palmoplantar Keratoderma Type 1	Palmoplantar Keratoderma, Punctate Type 1a
Palmoplantar Keratoderma, Punctate Type I	Keratoderma, Palmoplantar, Punctate Type Ia
Punctate Palmoplantar Keratoderma Type 1a	Punctate Palmoplantar Keratoderma Type 1b
Brauer-Buschke-Fischer Syndrome	Keratoderma, Palmoplantar Punctate Type 1
Type I Punctate Palmoplantar Keratoderma	Buschke-Fischer-Brauer Syndrome
Keratoderma, Palmoplantar, Punctate 1a	Keratodermia Palmoplantaris Papulosa Buschke-Fischer-Brauer Type
Keratosis Punctate Palmoplantaris Buschke-Fisher-Brauer Type	Punctate Palmoplantar Keratoderma Type Ia
Keratoderma, Palmoplantar, Punctate Type 1	Keratoderma, Palmoplantar, Punctate, Type Ia

Bacterial Pneumonia

Gram-Negative Pneumonia	Pneumonia Due To Other Gram-Negative Bacteria
Pneumonia Bacterial	Pneumonia, Bacterial
Acute Bacillus Pneumonia	Acute Bacterial Pneumonia
Bacillus Double Pneumonia	Bacillus Pneumonia
Bacteria Pneumonia	Bacterial Double Pneumonia
Bacterial Lobar Pneumonia	Bacterial Purulent Pneumonia
Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae

Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Dicer1 Syndrome

Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome	Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome
Ppb Familial Tumor Susceptibility Syndrome	Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome
Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility	Dicer1-Related Pleuropulmonary Blastoma
Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome	Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome
Ppbftds	Doid:0081063

Carotid Artery Disease

Carotid Artery Diseases

Disorder Of Carotid Artery

Pyelitis

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05982	HABP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HABP2	VGNC	VGNC:55955
Felis catus	HABP2	VGNC	VGNC:67531
Rattus norvegicus	HABP2	RGD	RGD:1302979
Canis familiaris	HABP2	VGNC	VGNC:52994
Macaca mulatta	HABP2	VGNC	VGNC:73341
Mus musculus	HABP2	MGD	MGI:1196378
Others	HABP2	NCBI

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