HBM - hemoglobin subunit mu Gene

Homo sapiens

Also known as HBK; HBAP2

Gene ID: 3042 | Gene type: protein coding

About HBM

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:165,978-166,764 (from NCBI)

This gene has 3 transcripts (splice variants), 66 orthologues and 11 paralogues.

Summary

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]

HBM Products(1)

mRNA	Protein	Name
NM_001003938.4	NP_001003938.1	hemoglobin subunit mu

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HBM Protein Structure

Globin

0
100
141 a.a.

Protein Preferred Names

Protein Names

hemoglobin subunit mu

alpha globin pseudogene 2

HBM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HBM	Q6B0K9	VIRMA	Homo sapiens	Q69YN4-4	Y2H Array	32296183
Intra	HBM	Q6B0K9	VIRMA	Homo sapiens	Q69YN4-4	Y2H Prey Pooling	32296183
Intra	HBM	Q6B0K9	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	HBM	Q6B0K9	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	HBM	Q6B0K9	HBG2	Homo sapiens	P69892	Y2H Array	32296183
Intra	HBM	Q6B0K9	HBG2	Homo sapiens	P69892	Y2H Prey Pooling	32296183
Intra	HBM	Q6B0K9	HBB	Homo sapiens	P68871	Y2H Prey Pooling	32296183
Intra	HBM	Q6B0K9	HBB	Homo sapiens	P68871	Y2H Array	32296183
Intra	HBM	Q6B0K9	HBZ	Homo sapiens	P02008	Y2H Prey Pooling	32296183
Intra	HBM	Q6B0K9	HBZ	Homo sapiens	P02008	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sclerosteosis 2

SOST2

Sclerosteosis, Type 2

Retinitis Pigmentosa 30

RP30	Retinitis Pigmentosa-30
Retinitis Pigmentosa, Type 30

Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99544	Tagitanlimab	Inhibitor	≥99.0%	Phase 3
HY-P99578	Tanfanercept	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0898A	(-)-Catechin	Inhibitor	98.78%	Unkown
HY-B1890	(±)-Catechin	Inhibitor	98.38%	Unkown
HY-147511	PPARγ agonist 7	Agonist	/	Unkown
HY-RS06032	HBM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990703	Porustobart		/	Unkown

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