ACAT2 - acetyl-CoA acetyltransferase 2 Gene

Rattus norvegicus

Also known as Acat3; Ab2-076

Gene ID: 308100 | Gene type: protein coding

About ACAT2

Primary_assembly 1: 47,695,788-47,752,821 forward strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 213 orthologues, 7 paralogues and is associated with 7 phenotypes. Biased expression in Liver (RPKM 12.4), Brain (RPKM 14.9) and 9 other tissues.

Summary

Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including bile acid signaling pathway; ketone body catabolic process; and liver development. Located in cytosol. Biomarker of premature menopause. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

ACAT2 Products(1)

mRNA	Protein	Name
NM_001006995.1	NP_001006996.1	acetyl-CoA acetyltransferase, cytosolic

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyl-CoA C-acetyltransferase activity	IDA IDA: Inferred from direct assay	10806397	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	11786296	RGD
involved in cellular response to nutrient	IEP IEP: Inferred from expression pattern	12563020	RGD
involved in ketone body catabolic process	IEP IEP: Inferred from expression pattern	5116556	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	5166591	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACAT2 Protein Structure

PRK05790

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

acetyl-CoA acetyltransferase, cytosolic

acetyl-Coenzyme A acetyltransferase 2	acetyl-Coenzyme A acetyltransferase 3
cytosolic acetoacetyl-CoA thiolase

Recombinant ACAT2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75543	ACAT2 Protein, Rat (His)	Q5XI22 (M1-G397)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13215	Avasimibe	Inhibitor	99.85%	Phase 3
HY-100401A	Pactimibe sulfate	Inhibitor	≥98.0%	Phase 3
HY-100401	Pactimibe	Inhibitor	99.98%	Phase 3
HY-100400A	K-604 dihydrochloride	Inhibitor	99.42%	Phase 2
HY-100399A	Nevanimibe hydrochloride	Inhibitor	99.92%	Phase 2
HY-100399	Nevanimibe	Inhibitor	/	Phase 2

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ACAT2	NCBI	NCBI:39

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