KCNIP2 - potassium voltage-gated channel interacting protein 2 Gene

Homo sapiens

Also known as KCHIP2

Gene ID: 30819 | Gene type: protein coding

About KCNIP2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,825,974-101,843,800 (from NCBI)

This gene has 14 transcripts (splice variants), 268 orthologues and 14 paralogues. Biased expression in fat (RPKM 117.8), heart (RPKM 37.5) and 1 other tissue.

Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each Other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

KCNIP2 Products(7)

mRNA	Protein	Name
NM_014591.5	NP_055406.2	Kv channel-interacting protein 2 isoform 1
NM_173191.3	NP_775283.1	Kv channel-interacting protein 2 isoform 2
NM_173192.3	NP_775284.1	Kv channel-interacting protein 2 isoform 3
NM_173193.3	NP_775285.1	Kv channel-interacting protein 2 isoform 4
NM_173194.3	NP_775286.1	Kv channel-interacting protein 2 isoform 5
NM_173195.3	NP_775287.1	Kv channel-interacting protein 2 isoform 6
NM_173197.3	NP_775289.1	Kv channel-interacting protein 2 isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to A-type (transient outward) potassium channel activity	IDA IDA: Inferred from direct assay	21349352	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15358149	GOA
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	21493962	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10551270	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21493962	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in action potential	IDA IDA: Inferred from direct assay	14980201	GOA
involved in clustering of voltage-gated potassium channels	IDA IDA: Inferred from direct assay	11287421	GOA
involved in membrane repolarization	IDA IDA: Inferred from direct assay	14980201	GOA
involved in muscle contraction	IDA IDA: Inferred from direct assay	11287421	GOA
involved in positive regulation of potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	21349352	GOA
involved in regulation of membrane repolarization	IDA IDA: Inferred from direct assay	21493962	GOA
involved in regulation of potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	21493962	GOA
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	21493962	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Kv4.2-KChIP2 channel complex	IPI IPI: Inferred from physical interaction	14980201	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11287421	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	21493962	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNIP2 Protein Structure

EF-hand_8

EF-hand_7

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

Kv channel-interacting protein 2

A-type potassium channel modulatory protein 2

KCNIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCNIP2	Q9NS61	KCND2	Homo sapiens	Q9NZV8	EM	14980201

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia Type 19/22

Sca19/22

Spinocerebellar Ataxia 19 And 22

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Spinocerebellar Ataxia 13

Spinocerebellar Ataxia Type 13	SCA13
Autosomal Dominant Cerebellar Ataxia With Intellectual Disability	Cerebellar Ataxia, Autosomal Dominant With Intellectual Disability
Spinocerebellar Ataxia-13	Ataxia, Spinocerebellar, Type 13

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome 2

LQT2	Long Qt Syndrome, Acquired, Reduced Susceptibility To
Long Qt Syndrome 1/2	Long Qt Syndrome 2/3
Long Qt Syndrome 2/5	Long Qt Syndrome 2, Acquired, Susceptibility To
Long Qt Syndrome, Acquired, Reduced	Long Qt Syndrome Type 2
Long Qt Syndrome 2/9	Lqt1/2
Lqt2/3	Lqt2/5
Lqt2/9	Susceptibility To Acquired Long Qt Syndrome 2
Long Qt Syndrome-2	Qt Syndrome, Long, Type 2
Long Qt Syndrome 1-2	Long Qt Syndrome 2-3
Long Qt Syndrome 2-5	Long Qt Syndrome 9

Heart Conduction Disease

Conduction Disorder Of The Heart

Heart Rhythm Disease

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07133	KCNIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNIP2	VGNC	VGNC:42255
Bos taurus	KCNIP2	VGNC	VGNC:30451
Macaca mulatta	KCNIP2	VGNC	VGNC:73833
Rattus norvegicus	KCNIP2	RGD	RGD:70887
Felis catus	KCNIP2	VGNC	VGNC:63041
Mus musculus	KCNIP2	MGD	MGI:2135916

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