Chuk - component of inhibitor of nuclear factor kappa B kinase complex Gene

Rattus norvegicus

Also known as Ikka; Ikbka

Gene ID: 309361 | Gene type: protein coding

About Chuk

Primary_assembly 1: 242,959,760-242,995,065 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 266 orthologues, 3 paralogues and is associated with 19 phenotypes. Biased expression in Kidney (RPKM 214.9), Liver (RPKM 178.7) and 9 other tissues.

Summary

Contributes to IkappaB kinase activity. Involved in several processes, including Rho protein signal transduction; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate Cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]

Chuk Products(1)

mRNA	Protein	Name
NM_001107588.1	NP_001101058.1	inhibitor of nuclear factor kappa-B kinase subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17419723	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to acetate	IEP IEP: Inferred from expression pattern	17543437	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17543437	RGD
involved in response to cholecystokinin	IDA IDA: Inferred from direct assay	12592100	RGD
involved in response to hydroperoxide	IEP IEP: Inferred from expression pattern	16028365	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	12361703	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16331110	RGD
involved in skeletal muscle contraction	IEP IEP: Inferred from expression pattern	15888549	RGD
involved in striated muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	11279241	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of IkappaB kinase complex	IDA IDA: Inferred from direct assay	17419723	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chuk Protein Structure

STKc_IKK_alpha

Ubl_IKKA_like

IKBKB_SDD

0
200
400
600
758 a.a.

Protein Preferred Names

Protein Names

inhibitor of nuclear factor kappa-B kinase subunit alpha

conserved helix-loop-helix ubiquitous kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02698	CHUK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02699	Chuk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02700	Chuk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chuk	NCBI	NCBI:1147

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