HLA-DOA - major histocompatibility complex, class II, DO alpha Gene

Homo sapiens

Also known as HLADZ; HLA-DNA; HLA-DZA

Gene ID: 3111 | Gene type: protein coding

About HLA-DOA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,004,182-33,009,591 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 89 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 26.6), spleen (RPKM 26.2) and 20 other tissues.

Summary

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

HLA-DOA Products(1)

mRNA	Protein	Name
NM_002119.4	NP_002110.1	HLA class II histocompatibility antigen, DO alpha chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class II protein complex binding	IDA IDA: Inferred from direct assay	22733780	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	22733780	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	22733780	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DOA Protein Structure

MHC_II_alpha

C1-set

0
100
200
250 a.a.

Protein Preferred Names

Protein Names

HLA class II histocompatibility antigen, DO alpha chain

HLA-D0-alpha

Related Diseases

Diseases

Alias

Hirata Disease

Insulin Autoimmune Syndrome

Insulin Autoimmune Hypoglycemia

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06201	HLA-DOA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HLA-DOA	RGD	RGD:3477
Mus musculus	HLA-DOA	MGD	MGI:95924

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