MAP3K7 - mitogen activated protein kinase kinase kinase 7 Gene

Rattus norvegicus

Also known as Tak1

Gene ID: 313121 | Gene type: protein coding

About MAP3K7

Primary_assembly 5: 46,357,931-46,415,597 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 113.9), Thymus (RPKM 113.1) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; positive regulation of intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytosol; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K7 Products(1)

mRNA	Protein	Name
NM_001107920.2	NP_001101390.2	mitogen-activated protein kinase kinase kinase 7

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16183734	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	28821620	RGD
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	16183734	RGD
enables histone kinase activity	IDA IDA: Inferred from direct assay	16125722	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	35352799	RGD
enables protein serine/threonine kinase binding	IDA IDA: Inferred from direct assay	34733837	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	27956576	RGD
enables type II transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	16360132	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	30760025	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	16183734	RGD
involved in cellular response to angiotensin	IDA IDA: Inferred from direct assay	20659889	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	32734729	RGD
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	16125722	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	32581266	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	20659889	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26002466	RGD
involved in negative regulation of voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	26584289	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	16183734	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	35078016	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	17947700	RGD
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	35078016	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	32971071	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	35078016	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	35078016	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16125722	RGD
involved in response to angiotensin	IEP IEP: Inferred from expression pattern	30854566	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	22388934	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K7 Protein Structure

STKc_TAK1

0
100
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300
400
500
606 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 7

TGF-beta activated kinase 1

mitogen-activated protein kinase kinase kinase 7-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-RS08062	MAP3K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08063	Map3k7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08064	MAP3K7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08065	MAP3K7CL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MAP3K7	NCBI	NCBI:6885

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