Epha4 - Eph receptor A4 Gene

Rattus norvegicus

Also known as RGD1560587

Gene ID: 316539 | Gene type: protein coding

About Epha4

Summary

Enables Ephrin Receptor binding activity. Involved in several processes, including regulation of modification of synaptic structure; regulation of neuron projection development; and synapse pruning. Located in several cellular components, including dendrite; distal axon; and perikaryon. Is integral component of plasma membrane. Is active in glutamatergic synapse. Biomarker of toxic encephalopathy. Orthologous to human EphA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Apr 2022]

Epha4 Products(1)

mRNA	Protein	Name
NM_001162411.1	NP_001155883.1	ephrin type-A receptor 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IDA IDA: Inferred from direct assay	10366629	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12775584	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glial cell migration	IMP IMP: Inferred from mutant phenotype	20335460	RGD
NOT involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	17418490	RGD
involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	17970742	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	19414612	RGD
involved in regulation of modification of synaptic structure	IGI IGI: Inferred from genetic interaction	24658113	RGD
involved in regulation of synapse pruning	EXP EXP: Inferred from Experiment	17143272	RGD
involved in regulation of synapse pruning	IDA IDA: Inferred from direct assay	17143272	RGD
involved in regulation of synapse pruning	IEP IEP: Inferred from expression pattern	17143272	RGD
involved in regulation of synapse pruning	IMP IMP: Inferred from mutant phenotype	17143272	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	19086003	RGD
located in axonal growth cone	IDA IDA: Inferred from direct assay	19086003	RGD
located in cell body	IDA IDA: Inferred from direct assay	19086003	RGD
located in cell projection	IDA IDA: Inferred from direct assay	19086003	RGD
located in cell surface	IDA IDA: Inferred from direct assay	19086003	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	12775584	RGD
located in dendrite	IDA IDA: Inferred from direct assay	19086003	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	24658113	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	19086003	RGD
located in filopodium	IDA IDA: Inferred from direct assay	19086003	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17143272	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17143272	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17143272	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	19086003	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	11414792	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	19086003	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17143272	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	17143272	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephrin type-A receptor 4

Recombinant Epha4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75238	EphA4 Protein, Rat (HEK293, His)	D3ZZK3 (V20-T547)	≥95%
HY-P75239	EphA4 Protein, Rat (HEK293, Fc)	D3ZZK3 (V20-T547)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159174	EPHA2/A4/GAK-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epha4	NCBI	NCBI:2043
Mus musculus	Epha4	NCBI	NCBI:13838
Macaca mulatta	Epha4	NCBI	NCBI:704857

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